P-10: Protective Effects of Satureja Khuzestanica Extract on Nonyl Phenol Induced Cytotoxicity in Sperm of Adult Mice

Background This study aimed to assess the protective effects of saturejakhuzistanica (SJKH) on sperm quality parameters in the Nonyl phenol (NP) - treated mice. MaterialsAndMethods In present experimental study, 32 young adult male mice (8-12 weeks) were randomly divided into four groups including control and test groups. The control group received corn oil orally, and the test groups were treated NP (250 mg/kg), SJKH (250 mg/kg), NP+SJKH (500 mg/kg) for 35 consecutive days orally by gavage. On day 35, after euthanasia the epididymal sperms were isolated. Then the total mean sperm count, sperm viability and motility were determined the total antioxidant capacity (TAOC) of all experimental groups were also evaluated. Results The NP-treated animals showed a significant changes in all parameters of sperm quality assessment compared to the control group. SJKH was able to protect from NP-induced effects on sperm maturity and DNA damage. Co-administration of NP and SJKH resulted in protection from NP reduced TAOC. Conclusion These data suggested that NP administration could adversely affect the sperm quality. Moreover, the protective effect of SJKH on NP-induced sperm toxicity was also documented.